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These include concerns regarding the long-term safety of gene modifications, challenges in the mass production of gene drugs, difficulties in controlling gene expression in vivo, limitations in achieving stable and long-term expression of foreign genes in vivo, low efficiency of targeted gene transfer, alterations in the biological properties of target cells, and ethical considerations

These models are vital for studying hematogenous dissemination and high-risk MB mechanisms

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Between 78% and 84% of those on the 10 mg or 15 mg dose lost at least 10% of their body weight

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