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Additionally, NETs can aid in mediating liver IRI, promoting tumor progression, and most recently, in mediating early graft rejection in liver transplantation

Throughout the process of pyroptosis, caspase 1 is responsible for cell swelling (Fink and Cookson, 2006), DNA fragmentation (Bergsbaken and Cookson, 2007), the arrest of cell metabolism (Shao et al., 2007), and other related functions (Figure 3)