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The 50100mg range appears in protocols because it approximates allometric scaling from effective rodent doses, but rigorous human pharmacokinetic data validating those numbers is sparse

Particularly, the 8-week EA effects could remain effective for 24 weeks following the treatment, indicating that acupuncture might be recommended as a valuable and promising new therapeutic option for patients with CFC

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This high prevalence suggests that the SARS-CoV-2 virus either rapidly depletes bodily stores of cobalamin during the acute infection phase or severely disrupts the gut microbiome's ability to absorb it post-infection

Source: The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis (2021) Methyl B12 as a syrup showed promising improvements in individuals with autism, most likely because it improved oxidative status