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McSweeney, M

Wheeler CJ

Inhibition of proliferation of human leukaemia 60 cells by diethyl esters of glyoxalase inhibitors in vitro

However, the prodrug technology still faces three key challenges in achieving precise treatment: off-target activation risks (such as premature release due to liver metabolism), tumor microenvironment [8] heterogeneity (such as the uneven distribution of hypoxia levels within the tumor, which hinders the effective release of hypoxia-activated prodrugs [9] and leads to poor treatment efficacy [3]), and insufficient temporal and spatial control accuracy

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