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Single-cell multi-omics approaches enable unprecedented resolution of metabolic heterogeneity, identifying distinct metabolic subpopulations and their vulnerabilities

The purified CPI2 protein migrated as a distinct band at approximately 14 kDa in SDS-PAGE, as shown in Figure 1A

According to a report published in 2019, more than 70% of deaths in the "opioid crisis" were caused by overdoses of synthetic opioids, mainly fentanyl and its derivatives

1502 days), 99 patients died, and cumulative survival rates were 82.3% at 1 year, 59.5% at 3 years, and 41.6% at 5 years

The preservation of proteostasis plays a crucial role in cell survival and becomes even more important for nondividing cells such as neurons, whose proteostasis machineries are reduced with aging, causing an accumulation of damaged organelles and misfolded proteins (327329)