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Interestingly, it has been previously reported that LMP2A enhances MYC driven lymphomagenesis through activation of the PI3K-pathway (181183), suggesting that activation of PI3K by LMP2A might be an alternative and/or convergent mechanism to the one driven by TCF3 / ID3 mutations

This is most likely to provide greater benefit if you have a metabolic disorder, an inflammatory condition, or are chronically restricting carbohydrate

While traditional pharmacological treatments are effective for many cases, a significant proportion of patients do not achieve full remission or experience side effects

doi: 10.1016/j.preteyeres.2007.01.004 98

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