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The pharmacokinetic advantage is significant: systemic bioavailability of intranasal peptides is typically 1020%, but CNS bioavailability can reach 3060% because the compound travels directly along nerve sheaths into cerebrospinal fluid

FOXO4-DRI was also tested in NZB/W mice BM-MSCs with similar apoptosis-inducing results

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Simultaneously, we also detected the transcriptional expression of some other factors in the Wnt/-Catenin signaling pathway

In fact, the first peptide therapy was aimed to support the production of insulin for diabetic patients