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J Pineal Res 2004

This unique biochemical feature of the double-stranded (ds)RNA-sensing TLR3 and the lipopolysaccharide (LPS)-sensing TLR4 is shared with a small subset of other PRRs, most notably the cytosolic DNA sensor cyclic GMPAMP synthase (cGAS) and the two dsRNA-sensing RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA-5) 6,7,8,9

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In response to genotoxic chemotherapy exposure, TNBC cells adaptively upregulate pyrimidine synthesis to increase the production of nucleotides necessary for DNA repair, whereas using leflunomide, a clinically approved inhibitor of de novo pyrimidine synthesis for the management of rheumatoid arthritis, sensitizes TNBC cells to chemotherapy and causes significant tumor regression when used in combination with doxorubicin 115

PNI is a pathological process that eventually leads to cancer cells invading peripheral nerves