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A recent study demonstrated improved survival in glioblastoma when the resection was extended beyond the area of enhancement into the T2/FLAIR abnormality, paving the way for not restricting surgical and radiotherapy target contours to only the contrast-enhancing portion identified on MRI 32

They are characterized by extreme spatiotemporal heterogeneity, as instead of possessing a single unique structure, they exist as dynamic, interconverting ensembles of multiple conformations

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Silymarin activates Nrf2 and upregulates phase II detoxification enzymes, including HO-1 and NQO1, while suppressing lipid peroxidation and mitochondrial ROS

This overlap often delays accurate diagnosis, allowing thalassemia to progress untreated or improperly managed in its early stages