You have a pre-existing medical condition, especially those involving the liver or kidneys
The over-abundance of ROS decreases collagen synthesis and increases collagen breakdown by stimulating matrix metalloproteinase (MMP) expression, eventually causing the alterations of the dermal matrix 5, 6
Pre-clinical trials have shown favorable toxicity results, and it is considered to be safe by most researchers
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The filters were then washed with 0.5 M ammonium bicarbonate to remove salts and dried in a 105 C oven for 24 h
