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(6) Therapeutic efficacy is highly time sensitive, with optimal outcomes occurring prior to completion of the aging process and markedly reduced oxime responsiveness after the post-aging window

It has been reported that the CPT1C isoform is overexpressed in human tumor cells such as neuroblastoma, several sarcomas of soft-tissues and lung, and malignant peripheral nerve sheath tumors (associated with neurofibromatosis type 1) 45

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