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Curcuminoids for the management of hypertriglyceridaemia

The GABA shunt is a pathway utilized in many organisms for the conversion of glutamate to succinate, via the formation of -aminobutyric acid (GABA) and succinic semialdehyde [83, 84]

As also the enzymes HGPRT (converts hypoxanthine to IMP) and adenylosuccinate synthase and adenylosuccinate lysase (amidate IMP to AMP) are expressed in astrocytes [236], it can be assumed that also inosine can serve as extracellular precursor for AMP synthesis and subsequently for ATP restoration

At the cellular level, vitamin C increases the mRNA levels of type I and type III collagen in the human dermis when skin biopsies were taken from areas on the forearm treated with topical vitamin C compared to skin that was not treated

Future studies combining these approaches with disease models of aging and disturbed flow should enable precision mapping of vascular metabolic remodeling and uncover novel targets to delay or prevent atherosclerosis in aging populations