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Firstly, GA significantly upregulates key drug-metabolizing enzyme genes (e.g., Cyp2b13 , Cyp2c69 , Cyp3a44 , Cyp3a16 , and Fmo3 ) that are downregulated by TGT, thereby enhancing liver detoxification capacity (Shi et al., 2021)

They are being investigated for a wide range of diseases, including cancer [4], metabolic disorders [5], autoimmune conditions [6], and wound healing [7, 8]

This finding provides an important clue into the underlying mechanism whereby -CG exerts adverse effects, although alteration in autophagic activity needs to be directly measured in future studies

1186/s40104-019-0371-4 Zhang, B., Lv, Z., Li, H., Guo, S., Liu, D., and Guo, Y

TLR4 and NFB levels, which were high in PTZ group were also reduced on treatment with Rhein, which also reversed the upregulation of the IKB protein which is an activator of NFB 55