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Discussion Although many antidepressants with different mechanisms are being used, a number of patients have not achieved appropriate therapeutic effects

When liver enlargement secondary to enzyme induction exceeds an adaptive response, there is hepatotoxicity

49 Moreover, administration of high doses of IL-1 fails to exacerbate APAP-induced liver injury, further suggesting a limited role of IL-1 signaling in the pathogenesis of APAP hepatotoxicity