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It is used to manage gestational diabetes, weight gain, prevent T2DM and treat polycystic ovarian syndrome [73]

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226 Cu deficiency can also alter the expression of myocardial gene profile, for example by upregulating the inflammatory cytokine TNF- and genes involved in regulating cardiac contractility, fibrosis, and calcium cycling, all of which may underlie the changes in cardiac function under Cu-deficient conditions