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Even though DOX cannot cross the bloodbrain barrier (BBB), it can cause substantial neurotoxicity with neuronal and synaptic loss, prompting cognitive deficits in the brain [39, 42] In the current work, DOX-induced oxidative stress was proved by higher levels of NOX4 and MDA, accompanied by loss of antioxidant defense mechanisms shown as lower GSH and SOD activities

[PubMed: 23359434] 244

We typically start with vagus nerve exercises like deep breathing, gargling, humming and singing, mindfulness & relaxation techniques like meditation, yoga and HRV training and optimizing sleep & circadian rhythms by having a consistent bedtime, focussing on morning sunlight exposure and more

Fate, activity, and impact of ingested bacteria within the human gut microbiota

Hum Reprod Update 5:172178 Sambandan TG, Rha C, Kadir AA, Aminudim N, Saad JM, inventors