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Long-term neuroplasticity research favors intermittent schedules

This idea is supported by our finding that TL shortening was associated with high levels of psychic anxiety but not high levels of depressed mood

Duclos M, Tabarin A

Its main mechanism appears to be its interaction with the nitric oxide (NO) system and its ability to upregulate growth factors like Vascular Endothelial Growth Factor (VEGF)