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Description

To determine the proportions of cells to assemble into composite structures, we first quantified the physiological proportions of the three cell types in vivo, finding an average of 15% cholangiocytes, 8% portal fibroblasts and 77% hepatocytes (Extended Data Fig

The key secondary efficacy endpoint was time to first event of clinical worsening, defined as a composite endpoint of all-cause mortality, hospitalization for worsening PAH or disease progression