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Melanin does not block enough UV to make sun time safe. Using less SPF is one of the fastest ways to stack damage, even if you do not see a burn

Microscopically, solid granules in a chronic inflammatory cell infiltrate present the same histopathologic aspect in both graphite and amalgam tattoos

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If this is true, then it is likely that either the upregulated process of melanin biosynthesis, the increased amount of melanin in the melanocytes, or both, occurring in the fields of benign oral melanin hyperpigmentation, constitute risk factors for transformation into oral mucosal melanomata

This is significantly longer than the few seconds of endogenous -MSH, but remains short compared to long-acting analogs such as subcutaneous afamelanotide implant (release over 60 days)