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Abbreviations VPA: Valproic acid JZ: Junctional zone LZ: Labyrinth zone DZ: Decidual zone NTDs: Neural tube defects HDAC: Histone deacetylase 5-Mthf: 5-Methyltetrahydrofolate ROS: Reactive oxygen species IL-6: Interleukin-6 HO-1: Heme oxygenase-1 GCs: Glycogen trophoblast cells TGCs: Trophoblast giant cells H&E: Hematoxylin and Eosin MTR: Methionine synthase THF: Tetrahydrofolate SB: Spina bifida HC: Hydrocephalus 5-mc: 5-Methylcytosine References Abdel-Latif RA et al (2023) Valproic acid-induced placental inflammation and oxidative stress in rats: protective effect of N-acetylcysteine

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Additionally, when aged cells excessively accumulate in the body, the release of highly reactive molecules such as reactive oxygen species and reactive nitrogen species (RNS) increases, inducing OS

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