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Browning of White Adipose Tissue Third, and perhaps most fascinating, NNMT inhibition promotes browning of white adipose tissue - the conversion of white adipocytes into beige/brown adipocytes that contain numerous mitochondria and express uncoupling protein 1 (UCP1), enabling them to dissipate energy as heat through non-shivering thermogenesis

Curr Opin Clin Nutr Metab Care 13(6):669676 Ghosh A, Ganguly S, Dey N, Banerjee S, Das A, Chattopadhyay DJ, Chatterjee IB (2015) Causation of cigarette smoke-induced emphysema by p-benzoquinone and its prevention by vitamin C

doi: 10.1371/journal.pone.0059051 22 LenerMRGuptaSScottRJTootsiMKulpMTammesooMLet al

This will mean absorption of vitamin B12 may not be possible

doi: 10.1159/000125652 247 KojimaMHosodaHDateYNakazatoMMatsuoHKangawaK