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When activated, NFkB regulates a variety of effector genes including antioxidants, ROS-producing proteins and pro-inflammatory genes (reviewed in 52 )

Neuropharmacology 2007

(1, 2) Key Takeaways Glutathione is the bodys master antioxidant, crucial for neutralizing free radicals, supporting the immune system, and protecting cells from oxidative stress

Abstract WHEN red cells deficient in glucose-6-phosphate (G-6-PD) are incubated with acetylphenylhydrazine under standardized conditions, there is a marked drop in concentration of reduced glutathione (GSH)

73,74,75 While suppression of the immune response is necessary to limit tissue damage during inflammation, in certain diseases, such as sepsis and cancer, it can lead to a breakdown of the immune defense system