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The procedures related to animal experiments were approved by Ethics Committee of Department of Laboratory Animals, Tongji University

Clc acted synergistically with pepsin under simulated gastric conditions and resisted pepsin degradation

The commonly reported adverse reactions included nausea, agitation, insomnia, and increased appetite [16]

The intensity of seizures due to fever in each animal was evaluated by measuring two factors: seizure threshold and the frequency of tonic-clonic seizures [12]