demonstrated that the inhibition of glycolysis strongly reduced the early phase of the oxygen consumption rate (as readout of the oxidative burst) and ROS release in mouse bone marrow-derived neutrophils stimulated with PMA, while inhibition of mitochondrial respiration impacted to a small degree late-phase ROS release (Furukawa et al., 2000
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Curcumin, beyond its direct cytotoxic and anti-proliferative actions on cancer cells, has garnered significant attention for its remarkable capacity to modulate the immune system, potentially shifting the balance towards an anti-tumorigenic response [62, 63]
Further, the authors of the review judged the quality of the evidence on which this result is based to be low or very low
