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As an example of a triprotic amino acid, let us consider arginine

This dimeric interaction is vital to the outcome of Fc:FcRn binding, as asymmetrical removal of FcRn binding to one of the two sides of the Fc drastically reduces both cellular transport and the plasma half-life of IgG [56, 59, 60]

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showed that isatuximab can preferentially block Tregs and enhance NK and CD8 + T-effector cell-mediated immune responses, effectively restoring immune effector functions against MM cells [31]