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YY: Writing original draft

TNF-, for instance, leads to impaired myocardial contractility by inhibiting beta-adrenergic receptor signaling 7

The same alkylation shift pattern was observed with strep-MBP-ROXY9- S CLC (Supplementary Fig

This type of metabolite ratio analysis can increase diagnostic efficacy by detecting changes not apparent when using an analysis of individual metabolites thereby providing information on biological processes that may not be discerned when studying only metabolite levels (34)