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This rate is much higher in the Northern Plains and much lower in the East, where the nongender related rates demonstrate the same overall trend

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It is very likely, therefore, that HIF-1's oxygen responsiveness resides over a permissive range of antioxidant buffering capacities, with the demonstration that the antioxidant/pro-oxidant equilibrium effectively uncouples HIF-1 activity from the normal pattern observed in response to variations in p O 2 in the alveolar epithelium [13, 14, 82]

Cell Stem Cell 18 (6), 827838 (2016)

However, high levels of IGFBP-3 in breast tumor tissues are associated with increased xenograft growth in mice and poor prognosis