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Results Inhibition of -oxidation alleviates ER stress in metabolically active cell types We have previously shown in vivo and in hepatoma cells in vitro that inhibiting -oxidation either pharmacologically or genetically diminishes ER stress signaling (Tyra, Spitz, & Rutkowski, 2012)

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Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria)