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Mitochondrial aldehyde dehydrogenase (Aldh2) rescues cardiac contractile dysfunction in an app/ps1 murine model of alzheimers disease via inhibition of acsl4-dependent ferroptosis

Bell GI, Najarian RC, Mullenbach GT, Hallewell RA

In this section, a comprehensive overview of the metabolic pathways of lactate is presented and its specific mechanistic roles, with particular emphasis on its dual role in regulating ferroptosis, are examined (Fig

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2 Materials and methods 2.1 Sample collection Thalli of B