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reported that matrix detachment of lung cancer cells induces a decrease in glucose uptake, activates LKB1 and AMPK, inhibits Ac-CoA carboxylases 1 and 2 which in turn, decreases NADPH consumption in fatty acid synthesis (FAS) while increasing NADPH generation through FAO fueling [118]

Furthermore, Ih inhibition enhances the AMPA/NMDAR-mediated response, indirectly regulates voltage-dependent Ca 2+ influx, and weakens GABA A receptor activity [166]

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PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

Barton-Davis ER, Shoturma DI, Musaro A, Rosenthal N, Sweeney HL (1998) Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function