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Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes
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Benefits of Liposomal Delivery Superior absorption and intracellular delivery of nutrients Phospholipid structure allows for effective delivery of compounds with different solubilities carried within the same particle (e.g., water- and lipid-soluble compounds) Liposomes penetrate the blood-brain barrier, an obstacle for other various formulations While there is an opportunity for quick absorption in the mouth, liposomes also survive the acidic environment of the stomach, ensuring intestinal uptake and delivery to the lymphatic system Liquid liposomal formulations are convenient for those who prefer to swallow fewer pills
(2001) Proceedings of the National Academy of Sciences (PNAS) , 98(22): 1243812443 Foundational study demonstrating that peptides from the amino-terminal MDM-2 binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells, establishing the basis for PNC-27s design
