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The metabolic samples were analysed by relative quantitative measures (i.e., fold change across biological conditions) using an internal standard method

Ordering of appropriate lab panels, often drawn in the clinic

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To further investigate the insulin-sensitizing effect conferred by MT1-MMP haploinsufficiency on skeletal muscle metabolism, the insulin-induced glucose disposal rate (IS-GDR), an indicator of insulin sensitivity of skeletal muscle and other peripheral tissues, was also measured