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Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C

N Engl J Med 2011, 365 (17):1576-1585

Group 1: normal saline (A,E,I) , group 2: hyaluronic acid (B,F,J) , group 3: AOD9604 (C,G,K) , Group 4: AOD9604 with hyaluronic acid (D,H,L) .

Although we were successful in ectopically expressing CDO in our cell culture system, the absolute level of maximal expression for either of the CDO constructs was far less than what is normally found in vivo