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In fact, the Cu 2+ -histidine interaction (binding) in nature can match the importance of iron (Fe 2+ ) binding with proteins, and the consequent haem interactions that support the very existence of life (Walton et al., 2023)

Not all hyperpigmentation is melasma, but all melasma is hyperpigmentation

Venous blood analysis showed that 76 CpG sites were differently methylated compared to control subjects (95 offspring of mothers with non-complicated pregnancies)

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VCO, on the other hand, is rich in medium-chain fatty acids and polyphenolic compounds that display high antioxidant and anti-inflammatory properties [58,59,60]