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4.2.6 Targeting ferroptosis for the treatment of AKI Given that ferroptosis is extensively involved in the occurrence and development mechanisms of various types of AKI, targeting the ferroptosis pathway may be a novel strategy for preventing and treating AKI

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1, 12 As the name implies, TJ acts as a physical barrier whose function is to prevent free passage of ions and small solutes through the space between two interacting cells

Nature (2019) 566:4036

Some of these methods include incorporating microgrooves into the interior surface of the conduit, filling the lumen with hydrogels, or using tissue-derived extracellular matrix (ECM) 13,14,15,16,17