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Historically, it has been possible to increase Glutathione levels through oral supplements or intravenous (IV) supplementation, however, these methods have generally been less effective and more expensive than other, newer options available today

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Acknowledgments The authors are grateful for the resources provided by the Deanship of Scientific Research at King Khalid University through the Large Groups Project under grant number R.G.P2/200/43

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Some of these adverse effects reported were Toxic Epidermal Necrolysis (a rare but life-threatening skin condition characterized by painful blisters and large areas of skin peeling), air embolism, thyroid dysfunction, and liver, kidney, and neurologic toxicity (The dark side of skin lightening- PubMed) With the proliferation of med-spas in an unregulated fashion, there is a risk of inadequately trained or untrained people giving IV injections in a non-sterile way, which can lead to sepsis and transmission of infections like HIV and hepatitis