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In addition, brain microglia-derived cytokines (IL-1, IL-6, IL-12, and TNF) become elevated and appear to facilitate disease progression [46]

Data examples We applied our IPQ method, along with six other methods (PB, STD, Nave, PPC, SPC and PQ-0.1) to three real data sets of meta-analysis, for testing the normality assumption about the distribution of true effect sizes across component studies