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Interestingly, we see marginal release of cytochrome c following 5FU and a transient dip in MOMP, but no enhanced difference in sensitivity to BH3-mimetics or increase in ATF4 expression or predicted activity in RNA-seq analysis (data not shown)

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All this to say, these are competitive results however the rates of diarrhea and vomiting could be a problem if they continue to develop the 6mg dose, and for Kailera, they need to conduct trials in the United States and elsewhere

Radiat Res 100:115123 Weiss JF, Hoover RL, Kumar KS (1987) Selenium pretreatment enhances the radioprotective effect and reduces the lethal toxicity of WR-2721