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By pretreating with a nanoprimer before LNPs loaded with RNA therapeutics, the bioavailability of RNA-loaded LNPs significantly improved (Saunders et al., 2020)

It is known that these chaperones can interact with key proteins in apoptotic signaling pathways (such as caspases) and regulate the nuclear factor-kappa B (NF-B) pathway and tumor necrosis factor (TNF)-mediated signal transduction, ultimately protecting cells and reducing heat stress-induced cell death [15]

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Importantly, this work also revealed the synaptic and behavioral abnormalities in these models of ASD [172, 173, 175] that were reversed by the selective nNOS inhibitor 7-nitroindasole [172, 173]