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Solutes such as NaCl and NaHCO3 and large sugars such as mannitol are assumed to be confined to the ECF compartment because they do not readily cross cell membranes

Both the Wnt receptor Frizzled3 and Frizzled6 are expressed in cochlear and vestibular hair cells in the inner ear, and double knockout mice for both receptors display PCP defects more penetrant in the cochlear than vestibular organs (Wang et al., 2006)

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Vitamin B12 shot side effects Most people tolerate vitamin B12 injections well, but possible side effects include: Mild: soreness or redness at injection site, mild diarrhea, nausea, headache, itching Rare but serious: allergic reactions (rash, swelling, difficulty breathing), low potassium (hypokalemia), dizziness or heart rate changes Get emergency medical help if you have signs of an allergic reaction to Vitamin B12: hives