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Disease development is not entirely explained by genetic predisposition, so other factors have been identified as potential players, such as early exposure to childhood viruses and altered intestinal bacterial composition [58]

Curr Med Chem 19(24):41574174 Liu E, Schmidt ME, Margolin R, Sperling R, Koeppe R, Mason NS, Klunk WE, Mathis CA, Salloway S, Fox NC, Hill DL (2015) Amyloid- 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials

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Without clinical data, an absolute upper limit cant be established

Choose a consistent day each week to make it a routine