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Lab tests show pp 332 activation leads to suppression of lipogenic gene expression and activation of genes involved in mitochondrial biogenesis

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[315] Comment: A few commenters recommended stratification by ED volume, with a commenter suggesting stratifying ED volume as small, medium, or large, to enable meaningful comparisons across hospitals with varying patient volume and resource levels

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Clinical trials measuring body composition found that fat mass reduction occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects