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Generally, it consists of phase I and phase II metabolizing enzyme systems in which, due to the activity of former, the epoxide can be formed that is an active form of carcinogen known to bind with the DNA, resulting in mutation during cell proliferation

Jang T, Mo G, Stewart C, Khoury L, Ferguson N, Egini O, Muthu J, Dutta D, Salifu M, Lim SH (2021) Hematopoietic stem cell transplant for sickle cell disease: patient selection and timing based on sickle cell-related multiple chronic conditions

Curr Opin Endocrinol Diabetes Obes 27:215224 Stancill JS, Corbett JA (2021) The role of thioredoxin/peroxiredoxin in the -cell defense against oxidative damage

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