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2011Jan25

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The constitutive activation has been documented in various cancers, including hepatocellular carcinoma, where it promotes chemoresistance, metabolic reprogramming favoring tumor growth, and evasion of apoptosis (78, 79)

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The D-phenylalanine (D-Phe) at position 4 further stabilises the receptor-bound conformation

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This adaptive response can result in GABAergic dysfunction, characterized by reduced inhibitory signaling

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Dopamine was first discovered in brain tissue by Katharine Montagu in 1957 (Montagu, 1957)

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