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It has been shown that when carbazole is present in human skin, for example in tattoo ink, prolonged exposure to sunlight resulting in photosensitized carbazole causes downregulation of antioxidant genes (hmox-1, keap-1, nrf-2, and bcl2) in HaCaT cells and of course an increase of ROS, with consequent apoptotic cell death ( In vitro experiments with HaCaT ( Thus, SOD protects human keratinocytes from UV-induced damage that includes aging caused by fragmentation of collagen and elastic fibers and activation of metalloproteases ( It seems that HaCaT cell lines become apoptotic in a dose-dependent way 24 h after radiation with 150 J/m 2 of UVB and only 35 J/m 2 of UVC ( Basal Cell and Spinocellular Carcinomas The skin is the organ generally most affected by tumors because it is the most exposed to environmental insults

Trans-Resveratrol improves cardiovascular health, enhances insulin sensitivity, provides neuroprotection, and supports healthy inflammatory responses

Thyroid autoimmunity is one of the risk factors for developing premature menopause (premature ovarian insufficiency) , indicating the impact of the autoimmune process on ovarian function ( Thyroid autoimmunity is associated with higher risk of POI 2021 )

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