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Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

SIRT1 is also known as the "longevity gene" because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular, kidney, liver, neurodegeneration and cancer

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Mitochondria, often called the powerhouses of cells, rely heavily on NAD+ for ATP synthesis