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In the CNS, IGF-1 has dual origins: one from the bloodstream, exerting endocrine effects upon entry into the CNS, and the other locally synthesized within the CNS, exerting autocrine/paracrine effects [25, 26]

Molecular mechanism of pancreatic stellate cells activation in chronic pancreatitis and pancreatic cancer

albicans may contribute to gastric cancer pathogenesis by reducing fungal diversity (212)

Ethics statement The animal study was reviewed and approved and the experiments were carried out in accordance with the international ethical standards for the use and care of laboratory animals and were approved by the Ethics Committee of Zagazig University (No

their metabolic reprogramming is tightly intertwined with metabolic crosstalk and collaborative adaptations involving other components within the tumor microenvironment