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For example, 2-propyl-2-pentenoic acid (2-en-VPA), a byproduct of -oxidation, and 2-propyl-4-pentenoic acid (4-en-VPA), a byproduct of -oxidation, have been incriminated in the development of cerebral oedema and in the hepatotoxicity of VPA, respectively [1724]

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The mainstream medical establishment has failed to recognize the urgent need to address the multiple, interrelated pathological features of Parkinson's disease in order to prevent further neuronal loss and slow disease progression

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