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doi:10.7860/JCDR/2016/18208.8127 9 Manchikanti L, Buenaventura RM, Manchikanti KN, et al

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Apoptosis, another consequence of oxidative damage and mitochondrial dysfunction, was evaluated using Annexin-V staining, which detects early apoptotic changes by binding to phosphatidylserine exposed on the outer leaflet of the plasma membrane

This explains why standard protocols use moderate doses rather than attempting to maximize peptide exposure

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