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If not normally distributed, the median (interquartile range) was used, and the MannWhitney U test was applied

Further investigation is required to establish the direct effect of urate-lowering treatment on cardiovascular/renal complications

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148 In an observational study that followed 222 subjects with a history of DVT for six years, those taking 200 mg pycnogenol per day had lower risks of recurrent DVT and post-thrombotic syndrome compared with those treated with blood thinner medications such as aspirin, ticlopidine (Ticlid), sulodexide (Aterina, a formulation composed of 80% low-molecular weight heparin), or no medication